Cell death can occur via several processes, few primary ones being necrosis, apoptosis, autophagy and entosis. For this, a process of death is required, which will not mount an immune response thereby protecting the neighbouring cells. A large number of these cells die every day to maintain tissue homeostasis. The body of a multicellular organism consists of trillions of cells. Since knockout models of various kinds have been used to study many aspects of germ cell development, a comprehensive summary of literature on knockout mice used in reproduction studies is also provided. One other important aspect that is covered in this review is microRNA-mediated control of germ cell apoptosis, a field of research that is going to see intense activity in near future. Since instances of germ cell carcinoma have increased over the past few decades, the current status of research on apoptotic pathways in teratocarcinoma cells is included. The review also discusses the importance of mechanisms pertaining to cellular apoptosis during testicular development, which is independent of exogenous stimuli. This review discusses the latest information available on male germ cell apoptosis induced by hormones, toxins and temperature in the context of the type of apoptotic pathway either the intrinsic or the extrinsic that may be used under a variety of stimuli. This is essential because mammalian spermatogenesis is a complex process that requires precise homeostasis of different cell types. Cellular apoptosis appears to be a constant feature in the adult testis and during early development.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |